Due by MAY 10 2021.
- Toxic responses of the endocrine system: Changes in hormones induced by antipsychotic drugs
Reference: Popovic, V., Doknic, M., Maric, N., Pekic, S. et al. (2007) Changes in neuroendocrine and metabolic hormones induced by atypical antipsychotics in normal-weight patients with schizophrenia. Neuroendocrinology 85:249-256.
- Rationale and design (10 points) –
- What evidence is cited in the paper of second-generation antipsychotic (SGA)-induced weight gain?
- What questions did they try to answer with their study?
- Was the study cross-sectional or prospective?
- In the design, what type of patients did they recruit? Why? What time points did they select for the study?
- Methods (10 points) –
- How did the authors select patients with schizophrenia and healthy controls? What inclusion/exclusion criteria were used?
- How did the authors measure hormone levels for insulin, growth hormone, ghrelin, leptin and prolactin? Was it mass spectrometry, fluorometric assays, RIAs (what are they?) or something else?
- Q3 – Patients compared to healthy controls (10 points) –
- What were three major differences between patients with schizophrenia (SCH) and healthy controls (Table 1 and text)?
- What is the significance of hormone differences for insulin (peak), cortisol, and prolactin?
- What is HOMA-IR?
- Effects of switch form First generation antipsychotic (FGA to SGA) (20 points)
- What were the major effects observed at 1 and 3 months compared to baseline? See Table 2 and Figure 1. What happened to BMI?
- What happened to levels of leptin, cortisol, prolactin and growth hormone?
- How did the authors interpret the changes in growth hormone, leptin and cortisol?
- What is their main conclusion?